Drug interactions
Carbamazepine + Osilodrostat
Severity: Moderate
Carbamazepine and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine may lower osilodrostat concentrations and reduce control of cortisol in Cushing's disease.
What this interaction means in plain words
Carbamazepine and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Osilodrostat belongs to Endocrine.
Why it happens
Carbamazepine induces CYP3A4, which contributes to osilodrostat metabolism.
What to do
Monitor urinary free cortisol and clinical signs of hypercortisolism and titrate osilodrostat upward as needed. Consider a non-inducing anticonvulsant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Carbamazepine with Osilodrostat?
MediHelp rates the interaction as moderate. Carbamazepine and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine may lower osilodrostat concentrations and reduce control of cortisol in Cushing's disease.
How serious is the interaction between Carbamazepine and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary free cortisol and clinical signs of hypercortisolism and titrate osilodrostat upward as needed. Consider a non-inducing anticonvulsant.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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