Drug interactions
Carbamazepine + Ospemifene
Severity: Moderate
Carbamazepine and Ospemifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine can reduce ospemifene concentrations, potentially diminishing efficacy for dyspareunia or vaginal dryness. Ospemifene is metabolised by several CYP enzymes that carbamazepine induces.
What this interaction means in plain words
Carbamazepine and Ospemifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Ospemifene belongs to Endocrine.
Why it happens
Carbamazepine induces CYP3A4, CYP2C9 and CYP2C19, increasing ospemifene clearance.
What to do
Monitor for reduced symptom relief and consider an alternative therapy if response is inadequate. Avoid relying on ospemifene dose escalation, as labeling does not support it.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
Frequently asked questions
Can I take Carbamazepine with Ospemifene?
MediHelp rates the interaction as moderate. Carbamazepine and Ospemifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine can reduce ospemifene concentrations, potentially diminishing efficacy for dyspareunia or vaginal dryness. Ospemifene is metabolised by several CYP enzymes that carbamazepine induces.
How serious is the interaction between Carbamazepine and Ospemifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced symptom relief and consider an alternative therapy if response is inadequate. Avoid relying on ospemifene dose escalation, as labeling does not support it.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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