Drug interactions
Carbamazepine + Paliperidone
Severity: Moderate
Carbamazepine and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine lowers paliperidone concentrations, which may reduce antipsychotic efficacy and risk relapse. The effect is clinically meaningful at usual carbamazepine doses.
What this interaction means in plain words
Carbamazepine and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Paliperidone belongs to Central Nervous System.
Why it happens
Carbamazepine induces P-glycoprotein and CYP3A4, increasing paliperidone elimination and reducing exposure.
What to do
Monitor clinical response and consider increasing the paliperidone dose when starting carbamazepine. Reduce the dose again if carbamazepine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Paliperidone?
MediHelp rates the interaction as moderate. Carbamazepine and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine lowers paliperidone concentrations, which may reduce antipsychotic efficacy and risk relapse. The effect is clinically meaningful at usual carbamazepine doses.
How serious is the interaction between Carbamazepine and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider increasing the paliperidone dose when starting carbamazepine. Reduce the dose again if carbamazepine is stopped.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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