Drug interactions
Carbamazepine + Piroxicam
Severity: Minor
Carbamazepine and Piroxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces CYP enzymes including CYP2C9 and may lower piroxicam concentrations. The practical result is likely a reduced analgesic or anti-inflammatory effect.
What this interaction means in plain words
Carbamazepine and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbamazepine belongs to Central Nervous System; Piroxicam belongs to Musculoskeletal.
Why it happens
Carbamazepine induces CYP2C9, accelerating piroxicam metabolism.
What to do
No routine dose change is needed. Review piroxicam efficacy and adjust the dose if symptom control is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Piroxicam?
MediHelp rates the interaction as minor. Carbamazepine and Piroxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbamazepine induces CYP enzymes including CYP2C9 and may lower piroxicam concentrations. The practical result is likely a reduced analgesic or anti-inflammatory effect.
How serious is the interaction between Carbamazepine and Piroxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Review piroxicam efficacy and adjust the dose if symptom control is inadequate.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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