Drug interactions
Carbamazepine + Rimegepant
Severity: Moderate
Carbamazepine and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 induction by carbamazepine is expected to reduce rimegepant exposure and diminish its effect in migraine.
What this interaction means in plain words
Carbamazepine and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Rimegepant belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 (and P-gp) increases rimegepant clearance.
What to do
Avoid concurrent use as recommended in labeling for strong or moderate CYP3A4 inducers. Use an alternative acute migraine agent if carbamazepine continues.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Rimegepant
Frequently asked questions
Can I take Carbamazepine with Rimegepant?
MediHelp rates the interaction as moderate. Carbamazepine and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong CYP3A4 induction by carbamazepine is expected to reduce rimegepant exposure and diminish its effect in migraine.
How serious is the interaction between Carbamazepine and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use as recommended in labeling for strong or moderate CYP3A4 inducers. Use an alternative acute migraine agent if carbamazepine continues.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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