Drug interactions
Carbamazepine + Solifenacin
Severity: Moderate
Carbamazepine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is a strong CYP3A4 inducer and can lower solifenacin concentrations, the drug being mainly metabolized by CYP3A4. This may reduce efficacy for overactive bladder.
What this interaction means in plain words
Carbamazepine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
CYP3A4 induction by carbamazepine increases solifenacin clearance.
What to do
Monitor for loss of symptom control and increase the solifenacin dose within labeled limits or switch agent if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Solifenacin?
MediHelp rates the interaction as moderate. Carbamazepine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine is a strong CYP3A4 inducer and can lower solifenacin concentrations, the drug being mainly metabolized by CYP3A4. This may reduce efficacy for overactive bladder.
How serious is the interaction between Carbamazepine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of symptom control and increase the solifenacin dose within labeled limits or switch agent if response is inadequate.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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