Drug interactions
Carbidopa + Hydrochlorothiazide-irbesartan
Severity: Minor
Carbidopa and Hydrochlorothiazide-irbesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbidopa, usually given with levodopa, can add to the blood-pressure-lowering effect of antihypertensives and cause orthostatic hypotension. The effect is mainly due to levodopa.
What this interaction means in plain words
Carbidopa and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbidopa belongs to Central Nervous System; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Additive hypotensive effect from dopaminergic therapy with antihypertensive vasodilation and volume reduction.
What to do
Check orthostatic blood pressure when starting or adjusting levodopa/carbidopa and reduce the antihypertensive dose if symptomatic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Carbidopa
Frequently asked questions
Can I take Carbidopa with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as minor. Carbidopa and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbidopa, usually given with levodopa, can add to the blood-pressure-lowering effect of antihypertensives and cause orthostatic hypotension. The effect is mainly due to levodopa.
How serious is the interaction between Carbidopa and Hydrochlorothiazide-irbesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check orthostatic blood pressure when starting or adjusting levodopa/carbidopa and reduce the antihypertensive dose if symptomatic.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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