Drug interactions
Carbinoxamine + Melatonin
Severity: Moderate
Carbinoxamine and Melatonin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a sedating first-generation antihistamine, and melatonin can add to drowsiness. This may impair alertness and psychomotor performance.
What this interaction means in plain words
Carbinoxamine and Melatonin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression from H1 antagonism and melatonin receptor-mediated sedation.
What to do
Warn the patient about additive drowsiness and avoid driving or hazardous tasks; reduce one agent if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Melatonin?
MediHelp rates the interaction as moderate. Carbinoxamine and Melatonin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbinoxamine is a sedating first-generation antihistamine, and melatonin can add to drowsiness. This may impair alertness and psychomotor performance.
How serious is the interaction between Carbinoxamine and Melatonin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about additive drowsiness and avoid driving or hazardous tasks; reduce one agent if sedation is excessive.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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