Drug interactions
Carbinoxamine + Mirtazapine
Severity: Moderate
Carbinoxamine and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are sedating antihistamines in effect, so together they can cause marked drowsiness and impaired alertness. Carbinoxamine's anticholinergic activity may add dry mouth and confusion, especially in older adults.
What this interaction means in plain words
Carbinoxamine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive H1-receptor antagonism and CNS depression.
What to do
Counsel on drowsiness and avoid driving until response is known. Consider a non-sedating antihistamine, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Mirtazapine?
MediHelp rates the interaction as moderate. Carbinoxamine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are sedating antihistamines in effect, so together they can cause marked drowsiness and impaired alertness. Carbinoxamine's anticholinergic activity may add dry mouth and confusion, especially in older adults.
How serious is the interaction between Carbinoxamine and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on drowsiness and avoid driving until response is known. Consider a non-sedating antihistamine, especially in older patients.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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