Drug interactions
Carbinoxamine + Modafinil
Severity: Minor
Carbinoxamine and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a sedating first-generation antihistamine and modafinil is a wakefulness-promoting agent, so effects on alertness may partly offset one another. Modafinil should not be assumed to prevent antihistamine-induced impairment.
What this interaction means in plain words
Carbinoxamine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbinoxamine belongs to Respiratory; Modafinil belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on CNS arousal; no established pharmacokinetic interaction.
What to do
Monitor for sedation and impaired performance and advise caution with driving. Choose a non-sedating antihistamine if drowsiness is a problem.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Modafinil?
MediHelp rates the interaction as minor. Carbinoxamine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbinoxamine is a sedating first-generation antihistamine and modafinil is a wakefulness-promoting agent, so effects on alertness may partly offset one another. Modafinil should not be assumed to prevent antihistamine-induced impairment.
How serious is the interaction between Carbinoxamine and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and impaired performance and advise caution with driving. Choose a non-sedating antihistamine if drowsiness is a problem.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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