Drug interactions
Carbinoxamine + Pregabalin
Severity: Moderate
Carbinoxamine and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a sedating antihistamine and its drowsiness adds to that of pregabalin. This can impair alertness and coordination, especially in older adults.
What this interaction means in plain words
Carbinoxamine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Pregabalin belongs to Central Nervous System.
Why it happens
Additive CNS depression from sedating H1 antihistamine and pregabalin.
What to do
Monitor for excess sedation and dizziness, and counsel against driving. Consider a non-sedating antihistamine if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pregabalin
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Pregabalin?
MediHelp rates the interaction as moderate. Carbinoxamine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbinoxamine is a sedating antihistamine and its drowsiness adds to that of pregabalin. This can impair alertness and coordination, especially in older adults.
How serious is the interaction between Carbinoxamine and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and dizziness, and counsel against driving. Consider a non-sedating antihistamine if appropriate.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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