Drug interactions
Cariprazine + Ceritinib
Severity: Major
Cariprazine and Ceritinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4, the main enzyme that metabolizes cariprazine and its active metabolites. Exposure to cariprazine may rise, increasing adverse effects such as akathisia, parkinsonism and sedation. The long half-life of the active metabolites prolongs the effect.
What this interaction means in plain words
Cariprazine and Ceritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cariprazine belongs to Central Nervous System; Ceritinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of cariprazine by ceritinib.
What to do
Cariprazine labeling advises dose reduction with strong CYP3A4 inhibitors; reduce the cariprazine dose and monitor for extrapyramidal symptoms. Reassess dosing again after ceritinib is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cariprazine
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Cariprazine with Ceritinib?
MediHelp rates the interaction as major. Cariprazine and Ceritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ceritinib inhibits CYP3A4, the main enzyme that metabolizes cariprazine and its active metabolites. Exposure to cariprazine may rise, increasing adverse effects such as akathisia, parkinsonism and sedation. The long half-life of the active metabolites prolongs the effect.
How serious is the interaction between Cariprazine and Ceritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Cariprazine labeling advises dose reduction with strong CYP3A4 inhibitors; reduce the cariprazine dose and monitor for extrapyramidal symptoms. Reassess dosing again after ceritinib is stopped.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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