Drug interactions
Cariprazine + Ergotamine
Severity: Moderate
Cariprazine and Ergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergotamine has serotonergic activity and cariprazine modulates serotonin and dopamine receptors, so a theoretical risk of serotonin toxicity or neuroleptic malignant syndrome exists. Reports for this pair are lacking and the risk is thought to be low. Cariprazine is mainly metabolized by CYP3A4, and ergotamine's own CYP3A4 handling does not make this a strong pharmacokinetic concern.
What this interaction means in plain words
Cariprazine and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Ergotamine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic and dopaminergic effects; the mechanism is theoretical.
What to do
Monitor for signs of serotonin toxicity such as agitation, tremor, hyperreflexia and fever, and for rigidity or hyperthermia suggesting neuroleptic malignant syndrome. Use the lowest effective ergotamine dose and limit how often it is taken.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cariprazine and Ergotamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cariprazine
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Cariprazine with Ergotamine?
MediHelp rates the interaction as moderate. Cariprazine and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ergotamine has serotonergic activity and cariprazine modulates serotonin and dopamine receptors, so a theoretical risk of serotonin toxicity or neuroleptic malignant syndrome exists. Reports for this pair are lacking and the risk is thought to be low. Cariprazine is mainly metabolized by CYP3A4, and ergotamine's own CYP3A4 handling does not make this a strong pharmacokinetic concern.
How serious is the interaction between Cariprazine and Ergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity such as agitation, tremor, hyperreflexia and fever, and for rigidity or hyperthermia suggesting neuroleptic malignant syndrome. Use the lowest effective ergotamine dose and limit how often it is taken.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
