Drug interactions
Cariprazine + Fedratinib
Severity: Moderate
Cariprazine and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor, and cariprazine and its active metabolites rely on CYP3A4 for clearance. Coadministration may increase cariprazine exposure and the risk of adverse effects such as akathisia, sedation and extrapyramidal symptoms. Its long-acting active metabolites make the effect prolonged.
What this interaction means in plain words
Cariprazine and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Fedratinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated cariprazine metabolism by fedratinib.
What to do
Monitor for increased adverse effects and consider reducing the cariprazine dose while fedratinib is used. Reassess for several weeks after either drug is stopped or started.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cariprazine and Fedratinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cariprazine
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Cariprazine with Fedratinib?
MediHelp rates the interaction as moderate. Cariprazine and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor, and cariprazine and its active metabolites rely on CYP3A4 for clearance. Coadministration may increase cariprazine exposure and the risk of adverse effects such as akathisia, sedation and extrapyramidal symptoms. Its long-acting active metabolites make the effect prolonged.
How serious is the interaction between Cariprazine and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased adverse effects and consider reducing the cariprazine dose while fedratinib is used. Reassess for several weeks after either drug is stopped or started.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
