Drug interactions
Cariprazine + Fenfluramine
Severity: Moderate
Cariprazine and Fenfluramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cariprazine blocks several serotonin receptors, which could reduce the serotonergic effect that underlies fenfluramine's seizure-reducing action. Both drugs can also cause somnolence, so sedation may be additive.
What this interaction means in plain words
Cariprazine and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Fenfluramine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at serotonin receptors plus additive CNS depression.
What to do
Monitor seizure frequency and sedation when the drugs are combined. Reassess the need for the antipsychotic if seizure control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Cariprazine with Fenfluramine?
MediHelp rates the interaction as moderate. Cariprazine and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cariprazine blocks several serotonin receptors, which could reduce the serotonergic effect that underlies fenfluramine's seizure-reducing action. Both drugs can also cause somnolence, so sedation may be additive.
How serious is the interaction between Cariprazine and Fenfluramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and sedation when the drugs are combined. Reassess the need for the antipsychotic if seizure control worsens.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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