Drug interactions
Cariprazine + Idelalisib
Severity: Major
Cariprazine and Idelalisib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A4 inhibitor and can raise cariprazine and active metabolite concentrations. This increases the risk of akathisia, parkinsonism and sedation.
What this interaction means in plain words
Cariprazine and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cariprazine belongs to Central Nervous System; Idelalisib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by idelalisib reduces cariprazine clearance.
What to do
Halve the cariprazine dose when combined with a strong CYP3A4 inhibitor and monitor for adverse effects for several weeks.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cariprazine and Idelalisib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
- Reagila 1.5 mg hard capsules - SmPC sections 4.3/4.5 (class statement: strong CYP3A4 inhibitors; "co-administration of cariprazine with strong CYP3A4 inhibitors (e.g. boceprevir, clarithromycin, cobicistat, indinavir, itraconazole, ketoconazole, nefazodone, ") — electronic medicines compendium (UK SmPC)
Other interactions of Cariprazine
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Cariprazine with Idelalisib?
MediHelp rates the interaction as major. Cariprazine and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A4 inhibitor and can raise cariprazine and active metabolite concentrations. This increases the risk of akathisia, parkinsonism and sedation.
How serious is the interaction between Cariprazine and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Halve the cariprazine dose when combined with a strong CYP3A4 inhibitor and monitor for adverse effects for several weeks.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
