Drug interactions
Cariprazine + Pregabalin
Severity: Moderate
Cariprazine and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin causes somnolence, dizziness and ataxia, and cariprazine may add to these effects. The combination may increase impairment of alertness and coordination and the risk of falls, particularly in older patients.
What this interaction means in plain words
Cariprazine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive central nervous system depression through different pharmacodynamic pathways.
What to do
Start low and titrate gradually while monitoring sedation, dizziness and falls. Advise against driving until the combined effect is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Pregabalin
Frequently asked questions
Can I take Cariprazine with Pregabalin?
MediHelp rates the interaction as moderate. Cariprazine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pregabalin causes somnolence, dizziness and ataxia, and cariprazine may add to these effects. The combination may increase impairment of alertness and coordination and the risk of falls, particularly in older patients.
How serious is the interaction between Cariprazine and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start low and titrate gradually while monitoring sedation, dizziness and falls. Advise against driving until the combined effect is known.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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