Drug interactions
Cariprazine + Rucaparib
Severity: Minor
Cariprazine and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak-to-moderate CYP3A4 inhibitor and may modestly raise cariprazine exposure. The clinical effect is likely small but could add to dose-related adverse effects.
What this interaction means in plain words
Cariprazine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cariprazine belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4 may slightly reduce cariprazine clearance.
What to do
No routine dose change is needed; monitor for akathisia, sedation and other adverse effects and adjust cariprazine if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cariprazine
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Cariprazine with Rucaparib?
MediHelp rates the interaction as minor. Cariprazine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak-to-moderate CYP3A4 inhibitor and may modestly raise cariprazine exposure. The clinical effect is likely small but could add to dose-related adverse effects.
How serious is the interaction between Cariprazine and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for akathisia, sedation and other adverse effects and adjust cariprazine if they occur.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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