Drug interactions
Cariprazine + Sevoflurane
Severity: Moderate
Cariprazine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cariprazine can add to the central nervous system depression and hypotensive effects of general anesthetics such as sevoflurane. Patients may have deeper sedation or lower blood pressure during and after anesthesia.
What this interaction means in plain words
Cariprazine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS depression and alpha-adrenergic related vasodilation.
What to do
Inform the anesthesia team of the antipsychotic therapy before surgery. Monitor hemodynamics and depth of anesthesia and titrate the anesthetic accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Sevoflurane
Frequently asked questions
Can I take Cariprazine with Sevoflurane?
MediHelp rates the interaction as moderate. Cariprazine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cariprazine can add to the central nervous system depression and hypotensive effects of general anesthetics such as sevoflurane. Patients may have deeper sedation or lower blood pressure during and after anesthesia.
How serious is the interaction between Cariprazine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of the antipsychotic therapy before surgery. Monitor hemodynamics and depth of anesthesia and titrate the anesthetic accordingly.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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