Drug interactions
Cariprazine + Stiripentol
Severity: Moderate
Cariprazine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces several CYP enzymes, including CYP3A4, which metabolizes cariprazine and its active metabolites. Exposure could change unpredictably, and both drugs can cause somnolence.
What this interaction means in plain words
Cariprazine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction by stiripentol altering cariprazine exposure, plus additive sedation.
What to do
Monitor for adverse effects such as akathisia, sedation and extrapyramidal symptoms, as well as loss of efficacy, and adjust cariprazine dose based on response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Stiripentol
Frequently asked questions
Can I take Cariprazine with Stiripentol?
MediHelp rates the interaction as moderate. Cariprazine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits and induces several CYP enzymes, including CYP3A4, which metabolizes cariprazine and its active metabolites. Exposure could change unpredictably, and both drugs can cause somnolence.
How serious is the interaction between Cariprazine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects such as akathisia, sedation and extrapyramidal symptoms, as well as loss of efficacy, and adjust cariprazine dose based on response.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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