Drug interactions
Carvedilol + Felbamate
Severity: Minor
Carvedilol and Felbamate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate inhibits some CYP enzymes, but CYP2C9 is a minor pathway for carvedilol, which is mainly cleared by CYP2D6 and CYP2C9 to a lesser extent. A clinically meaningful increase in carvedilol exposure is unlikely and would be modest at most.
What this interaction means in plain words
Carvedilol and Felbamate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Felbamate belongs to Central Nervous System.
Why it happens
Possible weak inhibition of the minor CYP2C9 pathway of carvedilol metabolism; not well established.
What to do
No dose change is routinely needed; check heart rate and blood pressure after felbamate is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carvedilol
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Carvedilol with Felbamate?
MediHelp rates the interaction as minor. Carvedilol and Felbamate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Felbamate inhibits some CYP enzymes, but CYP2C9 is a minor pathway for carvedilol, which is mainly cleared by CYP2D6 and CYP2C9 to a lesser extent. A clinically meaningful increase in carvedilol exposure is unlikely and would be modest at most.
How serious is the interaction between Carvedilol and Felbamate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; check heart rate and blood pressure after felbamate is started.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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