Drug interactions
Apalutamide + Felbamate
Severity: Moderate
Apalutamide and Felbamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may decrease felbamate levels, potentially reducing seizure control. The effect is likely moderate since felbamate is partly renally cleared.
What this interaction means in plain words
Apalutamide and Felbamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Felbamate belongs to Central Nervous System.
Why it happens
Apalutamide induces CYP3A4, increasing the portion of felbamate that is metabolized.
What to do
Monitor seizure frequency and felbamate concentrations, adjusting the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
- Brexpiprazole + Felbamate Moderate
Frequently asked questions
Can I take Apalutamide with Felbamate?
MediHelp rates the interaction as moderate. Apalutamide and Felbamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may decrease felbamate levels, potentially reducing seizure control. The effect is likely moderate since felbamate is partly renally cleared.
How serious is the interaction between Apalutamide and Felbamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and felbamate concentrations, adjusting the dose as needed.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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