Drug interactions
Asenapine + Felbamate
Severity: Moderate
Asenapine and Felbamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate can cause somnolence and dizziness, and with asenapine the sedative effects may add together. Antipsychotics may also lower seizure threshold.
What this interaction means in plain words
Asenapine and Felbamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Felbamate belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects of the two drugs.
What to do
Monitor for excessive sedation and for changes in seizure control. Reduce the dose of either drug if impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Bosentan + Felbamate Moderate
- Brexpiprazole + Felbamate Moderate
Frequently asked questions
Can I take Asenapine with Felbamate?
MediHelp rates the interaction as moderate. Asenapine and Felbamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felbamate can cause somnolence and dizziness, and with asenapine the sedative effects may add together. Antipsychotics may also lower seizure threshold.
How serious is the interaction between Asenapine and Felbamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and for changes in seizure control. Reduce the dose of either drug if impairment occurs.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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