Drug interactions
Felbamate + Ulipristal
Severity: Major
Felbamate and Ulipristal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate is a weak to moderate CYP3A4 inducer and may lower ulipristal concentrations. This could reduce emergency contraceptive efficacy.
What this interaction means in plain words
Felbamate and Ulipristal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Felbamate induces CYP3A4, increasing ulipristal clearance.
What to do
Avoid ulipristal and use a copper intrauterine device instead. Alternatively use levonorgestrel with a dose increase where guidance supports it.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Felbamate
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
- Brexpiprazole + Felbamate Moderate
Frequently asked questions
Can I take Felbamate with Ulipristal?
MediHelp rates the interaction as major. Felbamate and Ulipristal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Felbamate is a weak to moderate CYP3A4 inducer and may lower ulipristal concentrations. This could reduce emergency contraceptive efficacy.
How serious is the interaction between Felbamate and Ulipristal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ulipristal and use a copper intrauterine device instead. Alternatively use levonorgestrel with a dose increase where guidance supports it.
What other medicines interact with Felbamate?
MediHelp also lists interactions of Felbamate with, for example, Amisulpride, Amitriptyline, Apalutamide. The full list is on the Felbamate page.
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