Drug interactions
Bosentan + Felbamate
Severity: Moderate
Bosentan and Felbamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan may increase CYP3A4-mediated clearance of felbamate and reduce its levels. This could weaken seizure control in patients stabilised on felbamate.
What this interaction means in plain words
Bosentan and Felbamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosentan belongs to Miscellaneous; Felbamate belongs to Central Nervous System.
Why it happens
Bosentan induces CYP3A4, which contributes to felbamate metabolism.
What to do
Monitor seizure frequency and felbamate response after starting or stopping bosentan, and adjust the dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Cyclosporine Contraindicated
- Bosentan + Glyburide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Brexpiprazole + Felbamate Moderate
Frequently asked questions
Can I take Bosentan with Felbamate?
MediHelp rates the interaction as moderate. Bosentan and Felbamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan may increase CYP3A4-mediated clearance of felbamate and reduce its levels. This could weaken seizure control in patients stabilised on felbamate.
How serious is the interaction between Bosentan and Felbamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and felbamate response after starting or stopping bosentan, and adjust the dose if needed.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
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