Drug interactions
Amitriptyline + Felbamate
Severity: Moderate
Amitriptyline and Felbamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate inhibits CYP2C19 and may increase amitriptyline exposure, leading to more sedation and anticholinergic effects. Felbamate itself can cause CNS effects, which may add to the burden.
What this interaction means in plain words
Amitriptyline and Felbamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Felbamate belongs to Central Nervous System.
Why it happens
Felbamate inhibition of CYP2C19 reduces N-demethylation of amitriptyline.
What to do
Monitor for signs of tricyclic excess and consider lowering the amitriptyline dose. Check drug levels if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
- Brexpiprazole + Felbamate Moderate
Frequently asked questions
Can I take Amitriptyline with Felbamate?
MediHelp rates the interaction as moderate. Amitriptyline and Felbamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felbamate inhibits CYP2C19 and may increase amitriptyline exposure, leading to more sedation and anticholinergic effects. Felbamate itself can cause CNS effects, which may add to the burden.
How serious is the interaction between Amitriptyline and Felbamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of tricyclic excess and consider lowering the amitriptyline dose. Check drug levels if toxicity is suspected.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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