Drug interactions
Amisulpride + Felbamate
Severity: Moderate
Amisulpride and Felbamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate can cause somnolence and dizziness, and with amisulpride the sedation may be greater. Antipsychotics may also lower the seizure threshold in patients treated for epilepsy.
What this interaction means in plain words
Amisulpride and Felbamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Felbamate belongs to Central Nervous System.
Why it happens
Additive CNS depression; antipsychotic-related lowering of seizure threshold may oppose anticonvulsant effect.
What to do
Monitor for sedation and for any change in seizure control. Reduce doses if excessive drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
- Brexpiprazole + Felbamate Moderate
Frequently asked questions
Can I take Amisulpride with Felbamate?
MediHelp rates the interaction as moderate. Amisulpride and Felbamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felbamate can cause somnolence and dizziness, and with amisulpride the sedation may be greater. Antipsychotics may also lower the seizure threshold in patients treated for epilepsy.
How serious is the interaction between Amisulpride and Felbamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and for any change in seizure control. Reduce doses if excessive drowsiness occurs.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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