Drug interactions
Carvedilol + Givosiran
Severity: Moderate
Carvedilol and Givosiran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran may reduce CYP2D6 activity and thereby raise concentrations of CYP2D6 substrates such as carvedilol. This may lead to excess beta-blockade with bradycardia and hypotension.
What this interaction means in plain words
Carvedilol and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Givosiran belongs to Miscellaneous.
Why it happens
Inhibition of CYP2D6 metabolism by givosiran.
What to do
Monitor heart rate and blood pressure during givosiran treatment. Reduce the carvedilol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carvedilol and Givosiran, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Carvedilol
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Carvedilol with Givosiran?
MediHelp rates the interaction as moderate. Carvedilol and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran may reduce CYP2D6 activity and thereby raise concentrations of CYP2D6 substrates such as carvedilol. This may lead to excess beta-blockade with bradycardia and hypotension.
How serious is the interaction between Carvedilol and Givosiran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure during givosiran treatment. Reduce the carvedilol dose if bradycardia or hypotension develops.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
