Drug interactions
Carvedilol + Silodosin
Severity: Moderate
Carvedilol and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol blocks both beta and alpha-1 receptors, so combining it with silodosin gives overlapping alpha-1 blockade. This increases the likelihood of orthostatic hypotension, dizziness and syncope, especially at initiation.
What this interaction means in plain words
Carvedilol and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Silodosin belongs to Genitourinary.
Why it happens
Additive alpha-1 adrenergic blockade plus beta-blockade producing summed vasodilatory and hypotensive effects.
What to do
Start with low doses and titrate slowly, checking standing blood pressure. Take doses with food, and reduce or separate doses if orthostatic symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Silodosin?
MediHelp rates the interaction as moderate. Carvedilol and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carvedilol blocks both beta and alpha-1 receptors, so combining it with silodosin gives overlapping alpha-1 blockade. This increases the likelihood of orthostatic hypotension, dizziness and syncope, especially at initiation.
How serious is the interaction between Carvedilol and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and titrate slowly, checking standing blood pressure. Take doses with food, and reduce or separate doses if orthostatic symptoms occur.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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