Drug interactions
Cefaclor + Pretomanid
Severity: Minor
Cefaclor and Pretomanid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid inhibits the renal transporter OAT3 in vitro, which could reduce tubular secretion of cefaclor and raise its exposure. Higher cefaclor levels might increase dose-related adverse effects such as gastrointestinal upset or hypersensitivity-type reactions, although clinical data are lacking.
What this interaction means in plain words
Cefaclor and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefaclor belongs to Anti Bacterial; Pretomanid belongs to Anti Bacterial.
Why it happens
Pretomanid inhibits OAT3-mediated renal tubular secretion of cefaclor, based on in vitro data.
What to do
No routine dose change is needed for cefaclor, which has a wide therapeutic margin. Monitor for increased adverse effects, particularly in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefaclor
- Bcg vaccine live + Cefaclor Moderate
- Cefaclor + Cholera vaccine Moderate
- Cefaclor + Kanamycin Moderate
- Cefaclor + Microbiota Moderate
- Cefaclor + Plazomicin Moderate
- Cefaclor + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Other interactions of Pretomanid
Frequently asked questions
Can I take Cefaclor with Pretomanid?
MediHelp rates the interaction as minor. Cefaclor and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid inhibits the renal transporter OAT3 in vitro, which could reduce tubular secretion of cefaclor and raise its exposure. Higher cefaclor levels might increase dose-related adverse effects such as gastrointestinal upset or hypersensitivity-type reactions, although clinical data are lacking.
How serious is the interaction between Cefaclor and Pretomanid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed for cefaclor, which has a wide therapeutic margin. Monitor for increased adverse effects, particularly in patients with renal impairment.
What other medicines interact with Cefaclor?
MediHelp also lists interactions of Cefaclor with, for example, Bcg vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefaclor page.
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