Drug interactions
Cefaclor + Vadadustat
Severity: Minor
Cefaclor and Vadadustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits organic anion transporter 3, which contributes to renal secretion of some beta-lactams. Cefaclor exposure may therefore rise modestly, though cefaclor has a wide safety margin.
What this interaction means in plain words
Cefaclor and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefaclor belongs to Anti Bacterial; Vadadustat belongs to Endocrine.
Why it happens
Inhibition of renal OAT3-mediated tubular secretion of cefaclor by vadadustat.
What to do
No dose change is usually needed; watch for increased cefaclor adverse effects such as gastrointestinal upset or rash.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefaclor
- Bcg vaccine live + Cefaclor Moderate
- Cefaclor + Cholera vaccine Moderate
- Cefaclor + Kanamycin Moderate
- Cefaclor + Microbiota Moderate
- Cefaclor + Plazomicin Moderate
- Cefaclor + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Cefaclor with Vadadustat?
MediHelp rates the interaction as minor. Cefaclor and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vadadustat inhibits organic anion transporter 3, which contributes to renal secretion of some beta-lactams. Cefaclor exposure may therefore rise modestly, though cefaclor has a wide safety margin.
How serious is the interaction between Cefaclor and Vadadustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; watch for increased cefaclor adverse effects such as gastrointestinal upset or rash.
What other medicines interact with Cefaclor?
MediHelp also lists interactions of Cefaclor with, for example, Bcg vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefaclor page.
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