Drug interactions
Cefoxitin + Erythromycin lactobionate
Severity: Minor
Cefoxitin and Erythromycin lactobionate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macrolides are bacteriostatic and may theoretically blunt the bactericidal action of beta-lactams, which depend on actively dividing bacteria. Clinical evidence of reduced outcomes is sparse.
What this interaction means in plain words
Cefoxitin and Erythromycin lactobionate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefoxitin belongs to Anti Bacterial; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
Pharmacodynamic antagonism between a bacteriostatic agent and a bactericidal cell-wall inhibitor.
What to do
No routine change is needed. Monitor clinical response in severe infections when both are required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefoxitin
- Amikacin + Cefoxitin Moderate
- Aztreonam + Cefoxitin Moderate
- Bcg vaccine live + Cefoxitin Moderate
- Cefoxitin + Chloramphenicol Moderate
- Cefoxitin + Cholera vaccine Moderate
- Cefoxitin + Dexamethasone-tobramycin Moderate
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Cefoxitin with Erythromycin lactobionate?
MediHelp rates the interaction as minor. Cefoxitin and Erythromycin lactobionate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Macrolides are bacteriostatic and may theoretically blunt the bactericidal action of beta-lactams, which depend on actively dividing bacteria. Clinical evidence of reduced outcomes is sparse.
How serious is the interaction between Cefoxitin and Erythromycin lactobionate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor clinical response in severe infections when both are required.
What other medicines interact with Cefoxitin?
MediHelp also lists interactions of Cefoxitin with, for example, Amikacin, Aztreonam, Bcg vaccine live. The full list is on the Cefoxitin page.
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