Drug interactions
Cefpodoxime + Omeprazole
Severity: Moderate
Cefpodoxime and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefpodoxime proxetil needs gastric acidity for optimal dissolution and absorption, and acid suppressants lower its bioavailability. This may reduce antibacterial efficacy.
What this interaction means in plain words
Cefpodoxime and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefpodoxime belongs to Anti Bacterial; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH reduces dissolution and absorption of cefpodoxime proxetil.
What to do
Avoid combining where possible, or take cefpodoxime with food and consider another antibiotic if a PPI is essential.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Cefpodoxime
- Aluminum hydroxide + Cefpodoxime Moderate
- Amikacin + Cefpodoxime Moderate
- Calcium carbonate + Cefpodoxime Moderate
- Calcium + Cefpodoxime Moderate
- Cefpodoxime + Cholera vaccine Moderate
- Cefpodoxime + Cimetidine Moderate
Frequently asked questions
Can I take Cefpodoxime with Omeprazole?
MediHelp rates the interaction as moderate. Cefpodoxime and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefpodoxime proxetil needs gastric acidity for optimal dissolution and absorption, and acid suppressants lower its bioavailability. This may reduce antibacterial efficacy.
How serious is the interaction between Cefpodoxime and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, or take cefpodoxime with food and consider another antibiotic if a PPI is essential.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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