Drug interactions
Cefprozil + Estradiol
Severity: Minor
Cefprozil and Estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics were once thought to reduce the efficacy of oral estrogen-containing contraceptives by disrupting gut bacteria that recycle estrogens. Pharmacokinetic studies have generally not shown a meaningful drop in hormone levels with non-enzyme-inducing antibiotics, so any risk is very small.
What this interaction means in plain words
Cefprozil and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefprozil belongs to Anti Bacterial; Estradiol belongs to Endocrine.
Why it happens
Theoretical reduction of enterohepatic recirculation of estrogen through altered gut flora, not well supported.
What to do
No routine change is required. Advise patients using oral hormonal contraception to report vomiting or severe diarrhea, which can reduce absorption.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefprozil
- Amikacin + Cefprozil Moderate
- Bcg vaccine live + Cefprozil Moderate
- Cefprozil + Cholera vaccine Moderate
- Cefprozil + Gentamicin Moderate
- Cefprozil + Microbiota Moderate
- Cefprozil + Plazomicin Moderate
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Cefprozil with Estradiol?
MediHelp rates the interaction as minor. Cefprozil and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics were once thought to reduce the efficacy of oral estrogen-containing contraceptives by disrupting gut bacteria that recycle estrogens. Pharmacokinetic studies have generally not shown a meaningful drop in hormone levels with non-enzyme-inducing antibiotics, so any risk is very small.
How serious is the interaction between Cefprozil and Estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is required. Advise patients using oral hormonal contraception to report vomiting or severe diarrhea, which can reduce absorption.
What other medicines interact with Cefprozil?
MediHelp also lists interactions of Cefprozil with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefprozil page.
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