Drug interactions
Cefprozil + Hydrochlorothiazide
Severity: Minor
Cefprozil and Hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may compete with cefprozil for renal tubular secretion and slightly increase cefprozil exposure. The effect is usually modest and rarely clinically significant.
What this interaction means in plain words
Cefprozil and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefprozil belongs to Anti Bacterial; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Competition for renal tubular anionic secretion reduces cefprozil clearance.
What to do
No routine adjustment is needed. Consider monitoring renal function and cefprozil tolerability in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefprozil
- Amikacin + Cefprozil Moderate
- Bcg vaccine live + Cefprozil Moderate
- Cefprozil + Cholera vaccine Moderate
- Cefprozil + Gentamicin Moderate
- Cefprozil + Microbiota Moderate
- Cefprozil + Plazomicin Moderate
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Cefprozil with Hydrochlorothiazide?
MediHelp rates the interaction as minor. Cefprozil and Hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may compete with cefprozil for renal tubular secretion and slightly increase cefprozil exposure. The effect is usually modest and rarely clinically significant.
How serious is the interaction between Cefprozil and Hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Consider monitoring renal function and cefprozil tolerability in patients with renal impairment.
What other medicines interact with Cefprozil?
MediHelp also lists interactions of Cefprozil with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefprozil page.
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