Drug interactions
Ceftaroline fosamil + Probenecid
Severity: Minor
Ceftaroline fosamil and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid blocks renal tubular secretion of many beta-lactams and may raise ceftaroline's active metabolite exposure and prolong its half-life. The effect is usually not harmful given the wide therapeutic margin of ceftaroline.
What this interaction means in plain words
Ceftaroline fosamil and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ceftaroline fosamil belongs to Anti Bacterial; Probenecid belongs to Genitourinary.
Why it happens
Probenecid competitively inhibits organic anion transporters involved in renal tubular secretion of the drug.
What to do
No routine dose change is needed; be aware of higher exposure in patients with renal impairment and monitor for adverse effects such as rash or diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ceftaroline fosamil and Probenecid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ceftaroline fosamil
- Amikacin + Ceftaroline fosamil Moderate
- Ceftaroline fosamil + Cholera vaccine Moderate
- Ceftaroline fosamil + Gentamicin Moderate
- Ceftaroline fosamil + Kanamycin Moderate
- Ceftaroline fosamil + Microbiota Moderate
- Ceftaroline fosamil + Plazomicin Moderate
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Ceftaroline fosamil with Probenecid?
MediHelp rates the interaction as minor. Ceftaroline fosamil and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Probenecid blocks renal tubular secretion of many beta-lactams and may raise ceftaroline's active metabolite exposure and prolong its half-life. The effect is usually not harmful given the wide therapeutic margin of ceftaroline.
How serious is the interaction between Ceftaroline fosamil and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; be aware of higher exposure in patients with renal impairment and monitor for adverse effects such as rash or diarrhea.
What other medicines interact with Ceftaroline fosamil?
MediHelp also lists interactions of Ceftaroline fosamil with, for example, Amikacin, Cholera vaccine, Gentamicin. The full list is on the Ceftaroline fosamil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
