Drug interactions
Ceftaroline fosamil + Warfarin
Severity: Moderate
Ceftaroline fosamil and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics, including cephalosporins, can raise the INR in patients on warfarin and increase bleeding risk. The effect is variable and more likely in acutely ill patients with poor intake.
What this interaction means in plain words
Ceftaroline fosamil and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceftaroline fosamil belongs to Anti Bacterial; Warfarin belongs to Cardiovascular.
Why it happens
Probable reduction of vitamin K-producing gut flora; the mechanism for ceftaroline specifically is not established.
What to do
Check INR more often during and after ceftaroline therapy and adjust warfarin dose as needed. Advise the patient to report bleeding or bruising.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ceftaroline fosamil
- Amikacin + Ceftaroline fosamil Moderate
- Ceftaroline fosamil + Cholera vaccine Moderate
- Ceftaroline fosamil + Gentamicin Moderate
- Ceftaroline fosamil + Kanamycin Moderate
- Ceftaroline fosamil + Microbiota Moderate
- Ceftaroline fosamil + Plazomicin Moderate
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Ceftaroline fosamil with Warfarin?
MediHelp rates the interaction as moderate. Ceftaroline fosamil and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antibiotics, including cephalosporins, can raise the INR in patients on warfarin and increase bleeding risk. The effect is variable and more likely in acutely ill patients with poor intake.
How serious is the interaction between Ceftaroline fosamil and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR more often during and after ceftaroline therapy and adjust warfarin dose as needed. Advise the patient to report bleeding or bruising.
What other medicines interact with Ceftaroline fosamil?
MediHelp also lists interactions of Ceftaroline fosamil with, for example, Amikacin, Cholera vaccine, Gentamicin. The full list is on the Ceftaroline fosamil page.
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