Drug interactions
Ceftobiprole medocaril + Ezetimibe
Severity: Minor
Ceftobiprole medocaril and Ezetimibe: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftobiprole inhibits OATP1B1/1B3 in vitro and could raise ezetimibe levels. The clinical significance is likely limited given ezetimibe's wide safety margin.
What this interaction means in plain words
Ceftobiprole medocaril and Ezetimibe have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of OATP1B1/1B3 hepatic uptake of ezetimibe.
What to do
No dose adjustment is needed. Monitor for adverse effects during the short antibiotic course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ezetimibe
- Apalutamide + Ezetimibe Moderate
- Cholestyramine + Ezetimibe Moderate
- Cyclosporin + Ezetimibe Moderate
- Ezetimibe + Gemfibrozil Moderate
- Ezetimibe + Glecaprevir / pibrentasvir Moderate
- Ezetimibe + Letermovir Moderate
Frequently asked questions
Can I take Ceftobiprole medocaril with Ezetimibe?
MediHelp rates the interaction as minor. Ceftobiprole medocaril and Ezetimibe have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ceftobiprole inhibits OATP1B1/1B3 in vitro and could raise ezetimibe levels. The clinical significance is likely limited given ezetimibe's wide safety margin.
How serious is the interaction between Ceftobiprole medocaril and Ezetimibe?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for adverse effects during the short antibiotic course.
What other medicines interact with Ezetimibe?
MediHelp also lists interactions of Ezetimibe with, for example, Apalutamide, Cholestyramine, Cyclosporin. The full list is on the Ezetimibe page.
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