Drug interactions
Cyclosporin + Ezetimibe
Severity: Moderate
Cyclosporin and Ezetimibe: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine increases ezetimibe exposure several-fold, and ezetimibe may modestly raise cyclosporine concentrations. The effects are greater in patients with severe renal impairment and may increase the risk of adverse effects from either drug.
What this interaction means in plain words
Cyclosporin and Ezetimibe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Ezetimibe belongs to Cardiovascular.
Why it happens
Cyclosporine likely inhibits transporter-mediated uptake and disposition of ezetimibe, and ezetimibe may slightly alter cyclosporine concentrations through an incompletely defined mechanism.
What to do
Monitor cyclosporine trough concentrations after ezetimibe is started or stopped, and watch renal function and lipid response. Review muscle and liver adverse effects in these patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Ezetimibe
- Apalutamide + Ezetimibe Moderate
- Cholestyramine + Ezetimibe Moderate
- Ezetimibe + Gemfibrozil Moderate
- Ezetimibe + Glecaprevir / pibrentasvir Moderate
- Ezetimibe + Letermovir Moderate
- Ezetimibe + Sofosbuvir / velpatasvir Moderate
Frequently asked questions
Can I take Cyclosporin with Ezetimibe?
MediHelp rates the interaction as moderate. Cyclosporin and Ezetimibe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine increases ezetimibe exposure several-fold, and ezetimibe may modestly raise cyclosporine concentrations. The effects are greater in patients with severe renal impairment and may increase the risk of adverse effects from either drug.
How serious is the interaction between Cyclosporin and Ezetimibe?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough concentrations after ezetimibe is started or stopped, and watch renal function and lipid response. Review muscle and liver adverse effects in these patients.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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