Drug interactions
Ezetimibe + Letermovir
Severity: Moderate
Ezetimibe and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir can increase plasma concentrations of OATP1B1/3 substrates such as ezetimibe. The expected rise is modest, but it may increase the risk of ezetimibe-related adverse effects.
What this interaction means in plain words
Ezetimibe and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezetimibe belongs to Cardiovascular; Letermovir belongs to Anti Virals.
Why it happens
Letermovir inhibits OATP1B1/3 hepatic uptake transporters, reducing hepatic clearance of ezetimibe.
What to do
Monitor for myalgia and liver enzyme changes while letermovir is given. Dose adjustment is not usually necessary.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ezetimibe and Letermovir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ezetimibe
- Apalutamide + Ezetimibe Moderate
- Cholestyramine + Ezetimibe Moderate
- Cyclosporin + Ezetimibe Moderate
- Ezetimibe + Gemfibrozil Moderate
- Ezetimibe + Glecaprevir / pibrentasvir Moderate
- Ezetimibe + Sofosbuvir / velpatasvir Moderate
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Ezetimibe with Letermovir?
MediHelp rates the interaction as moderate. Ezetimibe and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir can increase plasma concentrations of OATP1B1/3 substrates such as ezetimibe. The expected rise is modest, but it may increase the risk of ezetimibe-related adverse effects.
How serious is the interaction between Ezetimibe and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myalgia and liver enzyme changes while letermovir is given. Dose adjustment is not usually necessary.
What other medicines interact with Ezetimibe?
MediHelp also lists interactions of Ezetimibe with, for example, Apalutamide, Cholestyramine, Cyclosporin. The full list is on the Ezetimibe page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
