Drug interactions
Apalutamide + Ezetimibe
Severity: Moderate
Apalutamide and Ezetimibe: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide induces UGT enzymes and may weakly induce OATP1B1, which are involved in ezetimibe disposition. This could lower ezetimibe exposure and may reduce its cholesterol-lowering effect.
What this interaction means in plain words
Apalutamide and Ezetimibe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Ezetimibe belongs to Cardiovascular.
Why it happens
Apalutamide induces UGT enzymes and weakly induces OATP1B1, increasing the clearance of ezetimibe.
What to do
Monitor the lipid profile after starting apalutamide and consider adjusting lipid-lowering therapy if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ezetimibe
- Cholestyramine + Ezetimibe Moderate
- Cyclosporin + Ezetimibe Moderate
- Ezetimibe + Gemfibrozil Moderate
- Ezetimibe + Glecaprevir / pibrentasvir Moderate
- Ezetimibe + Letermovir Moderate
- Ezetimibe + Sofosbuvir / velpatasvir Moderate
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Ezetimibe?
MediHelp rates the interaction as moderate. Apalutamide and Ezetimibe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide induces UGT enzymes and may weakly induce OATP1B1, which are involved in ezetimibe disposition. This could lower ezetimibe exposure and may reduce its cholesterol-lowering effect.
How serious is the interaction between Apalutamide and Ezetimibe?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the lipid profile after starting apalutamide and consider adjusting lipid-lowering therapy if the response is inadequate.
What other medicines interact with Ezetimibe?
MediHelp also lists interactions of Ezetimibe with, for example, Cholestyramine, Cyclosporin, Gemfibrozil. The full list is on the Ezetimibe page.
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