Drug interactions
Ezetimibe + Glecaprevir / pibrentasvir
Severity: Moderate
Ezetimibe and Glecaprevir / pibrentasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit hepatic uptake transporters and may raise ezetimibe plasma concentrations. The increase is probably of limited clinical consequence, but ezetimibe adverse effects such as myalgia or liver enzyme elevation could be more likely.
What this interaction means in plain words
Ezetimibe and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of OATP1B1/1B3 uptake transporters by glecaprevir and pibrentasvir reduces hepatic clearance of ezetimibe.
What to do
Monitor for muscle symptoms and liver enzyme abnormalities during the HCV treatment course. No empirical dose change is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ezetimibe
- Apalutamide + Ezetimibe Moderate
- Cholestyramine + Ezetimibe Moderate
- Cyclosporin + Ezetimibe Moderate
- Ezetimibe + Gemfibrozil Moderate
- Ezetimibe + Letermovir Moderate
- Ezetimibe + Sofosbuvir / velpatasvir Moderate
Frequently asked questions
Can I take Ezetimibe with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as moderate. Ezetimibe and Glecaprevir / pibrentasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit hepatic uptake transporters and may raise ezetimibe plasma concentrations. The increase is probably of limited clinical consequence, but ezetimibe adverse effects such as myalgia or liver enzyme elevation could be more likely.
How serious is the interaction between Ezetimibe and Glecaprevir / pibrentasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and liver enzyme abnormalities during the HCV treatment course. No empirical dose change is required.
What other medicines interact with Ezetimibe?
MediHelp also lists interactions of Ezetimibe with, for example, Apalutamide, Cholestyramine, Cyclosporin. The full list is on the Ezetimibe page.
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