Drug interactions
Ezetimibe + Gemfibrozil
Severity: Moderate
Ezetimibe and Gemfibrozil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemfibrozil increases total ezetimibe exposure by a modest amount. Both drugs raise biliary cholesterol excretion, so gallstone risk may be higher, and the combination is not recommended in labeling.
What this interaction means in plain words
Ezetimibe and Gemfibrozil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ezetimibe belongs to Cardiovascular; Gemfibrozil belongs to Cardiovascular.
Why it happens
Gemfibrozil raises ezetimibe plasma concentrations, probably by reducing its glucuronide clearance, and both drugs affect biliary cholesterol excretion.
What to do
Prefer fenofibrate if a fibrate is needed with ezetimibe. If combined, watch for biliary symptoms and consider gallbladder evaluation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ezetimibe
- Apalutamide + Ezetimibe Moderate
- Cholestyramine + Ezetimibe Moderate
- Cyclosporin + Ezetimibe Moderate
- Ezetimibe + Glecaprevir / pibrentasvir Moderate
- Ezetimibe + Letermovir Moderate
- Ezetimibe + Sofosbuvir / velpatasvir Moderate
Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Frequently asked questions
Can I take Ezetimibe with Gemfibrozil?
MediHelp rates the interaction as moderate. Ezetimibe and Gemfibrozil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemfibrozil increases total ezetimibe exposure by a modest amount. Both drugs raise biliary cholesterol excretion, so gallstone risk may be higher, and the combination is not recommended in labeling.
How serious is the interaction between Ezetimibe and Gemfibrozil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer fenofibrate if a fibrate is needed with ezetimibe. If combined, watch for biliary symptoms and consider gallbladder evaluation.
What other medicines interact with Ezetimibe?
MediHelp also lists interactions of Ezetimibe with, for example, Apalutamide, Cholestyramine, Cyclosporin. The full list is on the Ezetimibe page.
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