Drug interactions
Itraconazole + Sodium zirconium cyclosilicate
Severity: Moderate
Itraconazole and Sodium zirconium cyclosilicate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium zirconium cyclosilicate raises gastric pH, which can reduce the absorption of itraconazole capsules, whose dissolution depends on acidity. This may lead to subtherapeutic antifungal levels and treatment failure.
What this interaction means in plain words
Itraconazole and Sodium zirconium cyclosilicate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Sodium zirconium cyclosilicate belongs to Miscellaneous.
Why it happens
Increased gastric pH reduces dissolution and absorption of pH-dependent oral itraconazole.
What to do
Take itraconazole at least 2 hours before or after sodium zirconium cyclosilicate. Monitor clinical response or itraconazole levels in serious infections.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Sodium zirconium cyclosilicate
- Cefditoren + Sodium zirconium cyclosilicate Moderate
- Cefpodoxime + Sodium zirconium cyclosilicate Moderate
- Cefuroxime + Sodium zirconium cyclosilicate Moderate
- Crizotinib + Sodium zirconium cyclosilicate Moderate
- Dasatinib + Sodium zirconium cyclosilicate Moderate
- Erlotinib + Sodium zirconium cyclosilicate Moderate
Frequently asked questions
Can I take Itraconazole with Sodium zirconium cyclosilicate?
MediHelp rates the interaction as moderate. Itraconazole and Sodium zirconium cyclosilicate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium zirconium cyclosilicate raises gastric pH, which can reduce the absorption of itraconazole capsules, whose dissolution depends on acidity. This may lead to subtherapeutic antifungal levels and treatment failure.
How serious is the interaction between Itraconazole and Sodium zirconium cyclosilicate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take itraconazole at least 2 hours before or after sodium zirconium cyclosilicate. Monitor clinical response or itraconazole levels in serious infections.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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