Drug interactions
Celecoxib + Defibrotide
Severity: Moderate
Celecoxib and Defibrotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Defibrotide has profibrinolytic and antithrombotic properties and can increase bleeding risk when given with other drugs affecting hemostasis. Celecoxib adds a modest bleeding risk through GI mucosal injury. A P-glycoprotein effect is not a recognized mechanism.
What this interaction means in plain words
Celecoxib and Defibrotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Defibrotide belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects on hemostasis and mucosal integrity.
What to do
Monitor for bleeding and platelet count and hemoglobin during co-use. Consider avoiding NSAIDs in patients with active bleeding or severe thrombocytopenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Defibrotide
- Alteplase + Defibrotide Contraindicated
- Apixaban + Defibrotide Contraindicated
- Argatroban + Defibrotide Contraindicated
- Dabigatran etexilate + Defibrotide Contraindicated
- Dalteparin + Defibrotide Contraindicated
- Defibrotide + Edoxaban Contraindicated
Frequently asked questions
Can I take Celecoxib with Defibrotide?
MediHelp rates the interaction as moderate. Celecoxib and Defibrotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Defibrotide has profibrinolytic and antithrombotic properties and can increase bleeding risk when given with other drugs affecting hemostasis. Celecoxib adds a modest bleeding risk through GI mucosal injury. A P-glycoprotein effect is not a recognized mechanism.
How serious is the interaction between Celecoxib and Defibrotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and platelet count and hemoglobin during co-use. Consider avoiding NSAIDs in patients with active bleeding or severe thrombocytopenia.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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