Drug interactions
Celecoxib + Digoxin
Severity: Moderate
Celecoxib and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal function and glomerular filtration, which may raise digoxin concentrations in susceptible patients, particularly the elderly, those with heart failure, or with pre-existing renal impairment. Celecoxib has a smaller effect than other NSAIDs but renal effects can still occur.
What this interaction means in plain words
Celecoxib and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Digoxin belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins can lower renal perfusion and digoxin clearance.
What to do
Monitor renal function and serum digoxin levels when celecoxib is started or stopped, especially in at-risk patients. Reduce the digoxin dose if levels rise or toxicity signs appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Celecoxib with Digoxin?
MediHelp rates the interaction as moderate. Celecoxib and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal function and glomerular filtration, which may raise digoxin concentrations in susceptible patients, particularly the elderly, those with heart failure, or with pre-existing renal impairment. Celecoxib has a smaller effect than other NSAIDs but renal effects can still occur.
How serious is the interaction between Celecoxib and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and serum digoxin levels when celecoxib is started or stopped, especially in at-risk patients. Reduce the digoxin dose if levels rise or toxicity signs appear.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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