Drug interactions
Celecoxib + Fluconazole
Severity: Moderate
Celecoxib and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole substantially inhibits CYP2C9 and can increase celecoxib exposure, raising the risk of NSAID adverse effects such as GI bleeding, renal injury and cardiovascular events. Celecoxib labeling advises dose reduction with fluconazole.
What this interaction means in plain words
Celecoxib and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP2C9, the main pathway for celecoxib clearance.
What to do
Start celecoxib at the lowest recommended dose and reduce it as per labeling; monitor for GI, renal and cardiovascular adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Celecoxib with Fluconazole?
MediHelp rates the interaction as moderate. Celecoxib and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole substantially inhibits CYP2C9 and can increase celecoxib exposure, raising the risk of NSAID adverse effects such as GI bleeding, renal injury and cardiovascular events. Celecoxib labeling advises dose reduction with fluconazole.
How serious is the interaction between Celecoxib and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start celecoxib at the lowest recommended dose and reduce it as per labeling; monitor for GI, renal and cardiovascular adverse effects.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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