Drug interactions
Celecoxib + Glipizide
Severity: Moderate
Celecoxib and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib may modestly increase exposure to glipizide, a CYP2C9 substrate, and NSAIDs may potentiate hypoglycemia. Clinically significant hypoglycemia is uncommon but possible, especially in older or renally impaired patients.
What this interaction means in plain words
Celecoxib and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Glipizide belongs to Endocrine.
Why it happens
Competition for CYP2C9 metabolism may raise glipizide concentrations.
What to do
Monitor blood glucose after starting or stopping celecoxib and reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Glipizide
Frequently asked questions
Can I take Celecoxib with Glipizide?
MediHelp rates the interaction as moderate. Celecoxib and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib may modestly increase exposure to glipizide, a CYP2C9 substrate, and NSAIDs may potentiate hypoglycemia. Clinically significant hypoglycemia is uncommon but possible, especially in older or renally impaired patients.
How serious is the interaction between Celecoxib and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping celecoxib and reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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