Drug interactions
Celecoxib + Hydrochlorothiazide
Severity: Moderate
Celecoxib and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the diuretic and antihypertensive effect of thiazides. In volume-depleted or older patients the combination may also increase the risk of acute kidney injury.
What this interaction means in plain words
Celecoxib and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Celecoxib inhibits renal prostaglandin synthesis, causing sodium and water retention and reduced renal perfusion, which opposes thiazide action.
What to do
Monitor blood pressure, fluid status, serum creatinine and electrolytes, particularly in elderly or dehydrated patients. Ensure adequate hydration and use the lowest effective celecoxib dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Celecoxib with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Celecoxib and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the diuretic and antihypertensive effect of thiazides. In volume-depleted or older patients the combination may also increase the risk of acute kidney injury.
How serious is the interaction between Celecoxib and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, serum creatinine and electrolytes, particularly in elderly or dehydrated patients. Ensure adequate hydration and use the lowest effective celecoxib dose.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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