Drug interactions
Celecoxib + Levoketoconazole
Severity: Moderate
Celecoxib and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is an azole antifungal-derived cortisol synthesis inhibitor that inhibits CYP enzymes, and may raise celecoxib levels through CYP2C9 inhibition. Celecoxib adverse effects may therefore increase.
What this interaction means in plain words
Celecoxib and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Levoketoconazole belongs to Endocrine.
Why it happens
Inhibition of CYP2C9-mediated celecoxib metabolism.
What to do
Consider starting celecoxib at the lowest dose and monitor for adverse effects. Reduce the dose if exposure appears excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Celecoxib with Levoketoconazole?
MediHelp rates the interaction as moderate. Celecoxib and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is an azole antifungal-derived cortisol synthesis inhibitor that inhibits CYP enzymes, and may raise celecoxib levels through CYP2C9 inhibition. Celecoxib adverse effects may therefore increase.
How serious is the interaction between Celecoxib and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider starting celecoxib at the lowest dose and monitor for adverse effects. Reduce the dose if exposure appears excessive.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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